While desktop PCs offer several advantages over modern portable computing devices like laptops, tablets, and smartphones, prolonged mouse usage can negatively impact your wrist. A practical solution is to opt for an ergonomic mouse, which promotes a more neutral wrist position and provides improved support.

With a plethora of designs boasting various features and aesthetics, determining the best fit for you can be challenging. While personal preference plays a role in your choice, selecting one from our recommended options is a reliable method for choosing.

Logitech MX Vertical

• One of the best vertical designs
• Rubber and aluminum frame
• Wired and wireless options

• May be too expensive

Why you should buy this: Vertical mice give the most comfort long term, and this one is the best of the best.

Who it's for: People who will be scrolling on a computer screen for most of their day.

Why we picked the Logitech MX Vertical:

Building off developments in its other ergonomic mice, Logitech's MX Vertical is the company's first real attempt at a tall mouse that tackles the problems commonly associated with long-term mousing discomfort. Logitech claims it can offer up to a 10% reduction in muscle strain with extended usage. While that sort of metric is hard to test accurately, we did find it supremely comfortable during our testing. Better yet, it's intuitive and easy to get to grips with.

With a hefty but not overblown tilt angle of 57 degrees, the MX Vertical remains functional as an everyday mouse while still providing the benefits of a more ergonomic peripheral. Its natural wrist positioning forces you to rest your hand in a more conducive to long-term wrist health.

On top of all of its ergonomic features, this mouse looks good, too. Its combination of rubber and aluminum gives it a premium feel and finish that, for $100, feels well worth it to enjoy the benefits of ergonomic mousing. With wired and wireless options over Bluetooth (up to four months of battery life) and USB, it should work fine while you're on the move or when tethered to a desk. Despite stiff competition, the Logitech MX Vertical steams ahead as the best ergonomic mouse you can buy today.

Logitech MX Master 3s

• Sleek look
• Extremely comfortable
• Side scroll wheel is beyond convenient
• Notched or free-spin scroll wheel
• Incredible battery life

• Thumb rest gets dirty
• May be too heavy for some

Why you should buy this: It's a modern, comfortable ergonomic mouse.

Who it's for: People who don't want a vertical mouse, but still need something that is ergonomic.

Why we picked the Logitech MX Master 3s:

The Logitech MX Master 3s is very similar to the MX Master 3 in terms of appearances. However, the MX Master 3s stands out tahnsk to various enhancements. It features quieter left- and right-click buttons, an improved sensor with a broader CPI range of 8000Hz, and it utilizes Logitech's latest USB Bolt Receiver, while the earlier MX Master 3 employs Logitech's older Unifying USB Receiver.

The MX Master 3s is pretty durable and one of the best ergonomic mice on our list as it's made of stainless steel, not the traditional rubber material. It even works with multiple PCs, Macs, and tablets thanks to a handy switch on the bottom. The best part about Logitech's MX Master series is the MagSpeed electromagnetic scroll wheel that offers scroll speed of up to 1,000 lines per second for excellent accuracy. It comes with two modes -- a magnetic jump-scrolling mode for better control and a free-spinning mode that offers smooth and near-silent scrolling. Charging is done via USB-C and Logitech claims standby battery backup of up to 70 days.